In this report, we describe the near-infrared fluorescent probes called quinaldine red (QR) is lit β-sheet structure of amyloid fibrils. Photochemical and biophysical properties of QR along with the other canonical probe in the presence of amyloid protein fibrils were investigated using fluorescence spectroscopy, confocal fluorescent microscopy and isothermal titration calorimetry.

Moreover, the binding sites and modes of interaction between QR and insulin fibrils were calculated based on molecular docking. Among these amyloid probe, QR show several advantages including a strong force supramolecular, near-infrared emission, high sensitivity and resistance to bleaching. A linear response of the fluorescence intensity of a sample QR nerve in the presence of sera visualized in the range of 1-30 pM, with a limit of detection (LOD) of 2.31 pM.

Recovery and relative standard deviation (RSD) of the proposed method for the determination of protein fibrils is 90.4% -99.2% and 3.05% -3.47%, respectively. Finally, QR can be fluorescently shine when meeting with aberrant protein aggregates of rat pathogens. We recommend the QR as a new and very good alternative to monitor the transition of the amyloid protein conformation.

A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.
A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.

Dark quantitative determination of pseudo Explains Low Chromophore Population Quantum Yield Red Fluorescent Protein.

The results of four representative fluorescence quantum red fluorescent protein mCherry, mKate2, mRuby2 and recently introduced mScarlet investigated. Durability excited state is measured as a function of the distance to the gold mirror to control the local density of optical states (LDOs). By analyzing the total emission rate as a function of LDOs, we obtain separately the emission level and the level of non-radiation of the sunny countries. Thus we obtain for the first time the results of quantum states of light protein uninterrupted dark, non-emitting state. Bright state quantum yields are much higher than previously reported results of quantum that the average for both bright and dark states.

We determine that mCherry, mKate2 and mRuby2 have a considerable fraction of darker chromophore up to 45%, which explains the low quantum results measured red emitting protein reported in the literature and the difficulty in developing a high quantum results of variants of the protein. To light recently developed mScarlet we find a small dark much smaller than 14%, accompanied by a very high quantum results from sunny countries 81%. The presence of largely dark chromophores have implications for a variety of fluorescent protein applications, ranging from quantitative fluorescence microscopy, FRET studies, to monitor protein expression levels.

We recommend that future optimization of the red fluorescent protein should pay more attention to minimize protein fractions dark. genetically encoded fluorescent protein (FP) are used in cell biology research to study the protein of interest or a signal process using a biosensor. To perform well in certain applications, it requires a lot of properties FP adjusted. It is for this reason that they need to be optimized by using mutagenesis. Process optimization through screening often based on the brightness of the colonies of bacteria, but some parameters ultimately determine the optimal performance of an FP.

R Phycoerythrin antibody

70R-10657 1 mg
EUR 219
Description: Goat polyclonal R Phycoerythrin antibody

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70R-10691 1 mg
EUR 176
Description: Rabbit polyclonal R Phycoerythrin antibody

PE [R-Phycoerythrin] *CAS 11016-17-4*

2556 10 mg
EUR 219

PE [R-Phycoerythrin] *CAS 11016-17-4*

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Description: Donkey anti Human IgG Secondary Antibody (R-Phycoerythrin)

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20005-11-PE 25 tests
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20007-G1-PE 100 tests
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Recombinant (E. coli) Red Fluorescent Proteins (RFP/dsRed) protein for ELISA or Standards (>98%)

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Streptavidin, R-phycoerythrin conjugate, 0.5 mg/mL

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Annexin V, R-phycoerythrin conjugate (100 assays)

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20009-Fc-PE 100 tests
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1P-722-C025 0.025 mg
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5-01865 4 x 5mg Ask for price


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B6909-10 10 mg
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EUR 479


EUR 294

Rabbit IgG F(ab')2-R-PE conjugate, isotype control

20009-FAb2-PE 100 tests
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MCD120A-PE 100 tests
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0.65ml Tube, Red, 1000/Bag

BT613-R 1PK, 1000UNIT
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10121-PE 0.5 ml
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10122-PE 0.5 ml
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10123-PE 0.5 ml
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Mouse Monoclonal Anti-Human IgG4 (Fc-region)-PE (phycoerythrin) conjugate

10124-PE 0.5 ml
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(R,R)-Secoisolariciresinol diglucoside

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(R,R)-Palonosetron Hydrochloride

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R-S-R Peptide

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Anti-CD63 R-PE antibody

STJ16100872 100 tests
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GFP15-R 10 ug
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R541-R 1 UNIT
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RH504-R 1 UNIT
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MCD120b-PE 100 tests
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5-00521 4 x 5mg Ask for price


TBZ0092 unit Ask for price

Enhanced Green Fluorescent Proteins (EGFP) protein for ELISA or Standards

EGFP16-R 10 ug
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A-K-R-R-R-L-S-S-L-R-A Peptide

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Description: Micro Tubes; Micro Tubes Push Cap- Axygen

R-Cadherin (R-cadherin) Antibody

abx237200-100ug 100 ug
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4-Ways Microtube and Centrifuge Tubes Racks, Red

R023-R 1 UNIT
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Goat anti Human IgA (R-PE)

43R-1662 100 ug
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Description: Goat anti Human IgA antibody conjugated to R-Phycoerythrin

Recombinant (E. coli) Yellow Fluorescent Proteins (YFP) protein for ELISA or Standards (>98%)

YFP15-R 25 ug
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R synuclein protein

30R-3036 200 ug
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Description: Purified recombinant R synuclein protein

R-phycoerythrin goat anti-mouse IgG(H+L), 0.5 mg/mL

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R-phycoerythrin goat anti-rabbit IgG(H+L), 0.5 mg/mL

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Streptavidin-Phycoerythrin (PE) conjugate

20369 0.5 ml
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LVP933 1x107 IFU/ml x 200ul
EUR 451
Description: Pre-made over-expression lentivirus for expressing Rat target: IGF1R ( insulin-like growth factor 1 receptor), [alternative names: IGF-1 receptor; IGFIRC; Igfr1; JTK13]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_052807.2. It also contains a RFP-Blasticidin dual selection marker.

R 80123

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Instead of the selection of the characteristics of other properties, we develop a multiparameter method of screening based on four critical parametersscreened simultaneously: fluorescence lifetime, brightness cellular maturation efficiency and photostability.