In this report, we describe the near-infrared fluorescent probes called quinaldine red (QR) is lit β-sheet structure of amyloid fibrils. Photochemical and biophysical properties of QR along with the other canonical probe in the presence of amyloid protein fibrils were investigated using fluorescence spectroscopy, confocal fluorescent microscopy and isothermal titration calorimetry.

Moreover, the binding sites and modes of interaction between QR and insulin fibrils were calculated based on molecular docking. Among these amyloid probe, QR show several advantages including a strong force supramolecular, near-infrared emission, high sensitivity and resistance to bleaching. A linear response of the fluorescence intensity of a sample QR nerve in the presence of sera visualized in the range of 1-30 pM, with a limit of detection (LOD) of 2.31 pM.

Recovery and relative standard deviation (RSD) of the proposed method for the determination of protein fibrils is 90.4% -99.2% and 3.05% -3.47%, respectively. Finally, QR can be fluorescently shine when meeting with aberrant protein aggregates of rat pathogens. We recommend the QR as a new and very good alternative to monitor the transition of the amyloid protein conformation.

A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.
A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.

Dark quantitative determination of pseudo Explains Low Chromophore Population Quantum Yield Red Fluorescent Protein.

The results of four representative fluorescence quantum red fluorescent protein mCherry, mKate2, mRuby2 and recently introduced mScarlet investigated. Durability excited state is measured as a function of the distance to the gold mirror to control the local density of optical states (LDOs). By analyzing the total emission rate as a function of LDOs, we obtain separately the emission level and the level of non-radiation of the sunny countries. Thus we obtain for the first time the results of quantum states of light protein uninterrupted dark, non-emitting state. Bright state quantum yields are much higher than previously reported results of quantum that the average for both bright and dark states.

We determine that mCherry, mKate2 and mRuby2 have a considerable fraction of darker chromophore up to 45%, which explains the low quantum results measured red emitting protein reported in the literature and the difficulty in developing a high quantum results of variants of the protein. To light recently developed mScarlet we find a small dark much smaller than 14%, accompanied by a very high quantum results from sunny countries 81%. The presence of largely dark chromophores have implications for a variety of fluorescent protein applications, ranging from quantitative fluorescence microscopy, FRET studies, to monitor protein expression levels.

We recommend that future optimization of the red fluorescent protein should pay more attention to minimize protein fractions dark. genetically encoded fluorescent protein (FP) are used in cell biology research to study the protein of interest or a signal process using a biosensor. To perform well in certain applications, it requires a lot of properties FP adjusted. It is for this reason that they need to be optimized by using mutagenesis. Process optimization through screening often based on the brightness of the colonies of bacteria, but some parameters ultimately determine the optimal performance of an FP.

R Phycoerythrin antibody

70R-10657 1 mg
EUR 219
Description: Goat polyclonal R Phycoerythrin antibody

R Phycoerythrin antibody

70R-10691 1 mg
EUR 176
Description: Rabbit polyclonal R Phycoerythrin antibody

PE [R-Phycoerythrin] *CAS 11016-17-4*

2556 10 mg
EUR 219

PE [R-Phycoerythrin] *CAS 11016-17-4*

2557 100 mg
EUR 550

PE [R-Phycoerythrin] *CAS 11016-17-4*

2558 1 mg
EUR 115

ReadiUse™ PE [R-Phycoerythrin] *Ammonium Sulfate-Free*

2500 1 mg
EUR 132

ReadiUse™ PE [R-Phycoerythrin] *Ammonium Sulfate-Free*

2501 10 mg
EUR 480

Donkey anti Human IgG (R-Phycoerythrin)

43R-1654 1 ml
EUR 534
Description: Donkey anti Human IgG Secondary Antibody (R-Phycoerythrin)

Recombinant (E. coli) Red Fluorescent Proteins (RFP/dsRed) protein for ELISA or Standards (>98%)

RFP15-R 25 ug
EUR 250

Rat IgG1-R-PE conjugate (isotype control)

20005-11-PE 25 tests
EUR 202

Rat IgG2a-R-PE conjugate (isotype control)

20005-12-PE 25 tests
EUR 202

Rat IgG2b-R-PE conjugate (isotype control)

20005-13-PE 25 tests
EUR 202

Rat IgG2c-R-PE conjugate (isotype control)

20005-14-PE 50 tests
EUR 250

Rat IgM-R-PE conjugate (isotype control)

20005-21-PE 25 tests
EUR 202

Human IgG1-R-PE Conjugate (-ve control)

20007-G1-PE 100 tests
EUR 225

Streptavidin, R-phycoerythrin conjugate, 0.5 mg/mL

9-29044
  • EUR 288.00
  • EUR 153.00
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

Annexin V, R-phycoerythrin conjugate (100 assays)

9-29045
  • EUR 149.00
  • EUR 312.00
  • 100uL
  • 500uL
Description: Minimum order quantity: 1 unit of 500uL

Hamster IgG-R-PE conjugate, isotype control (Syrian)

20003-1-PE 50 tests
EUR 225

Safe-Red™

G108-R 1.0 ml
EUR 71

80 WELL RED MICROTUBE RACK FOR 1.5/2.0ML MICROTUBES

R-80-R 5/pk
EUR 94
Description: Micro Tubes; Racks Tubes - Axygen

Anti-R-RAS2 PE

1P-722-C025 0.025 mg
EUR 195

Anti-R-RAS2 PE

1P-722-C100 0.1 mg
EUR 349

R-Ras2 Antibody (PE)

abx140419-01mg 0.1 mg
EUR 648

Rabbit IgG F(c)-R-PE conjugate, isotype control

20009-Fc-PE 100 tests
EUR 225

Goat IgG F(ab')2 fragment-R-PE conjugate

20011-FAB2-PE 50 tests
EUR 202

R-S-R

5-01865 4 x 5mg Ask for price

(R,R)-Dipamp

20-abx181460
  • EUR 690.00
  • EUR 370.00
  • 1 g
  • 250 mg

(R,R)-THC

B6909-10 10 mg
EUR 583

(R,R)-Hymeglusin

B1244-1000
EUR 479

(R,R)-Hymeglusin

B1244-500
EUR 294

Rabbit IgG F(ab')2-R-PE conjugate, isotype control

20009-FAb2-PE 100 tests
EUR 225

Floating Microtube Racks Octagon, Red

R021-R 1 UNIT
EUR 51.7

50-Well Microtube Racks, Red

R022-R 1 UNIT
EUR 53.05

40-Well Microtube Racks, Red

R027-R 1 UNIT
EUR 53.05

0.65ml Tube, Red, 1000/Bag

BT613-R 1PK, 1000UNIT
EUR 68.4

Green Fluorescent Proteins (GFP) protein for ELISA or Standards

GFP15-R 10 ug
EUR 250

Rat Monoclonal Anti-Mouse CD120a (TNF-R, p55), PE (Clone HM104) (rat IgG2a)

MCD120A-PE 100 tests
EUR 408

(R,R)-Palonosetron Hydrochloride

HY-A0021C 10mg
EUR 946

(R,R)-Secoisolariciresinol diglucoside

HY-N6937 5mg
EUR 108

R-S-R Peptide

20-abx265906
  • EUR 370.00
  • EUR 565.00
  • EUR 286.00
  • 10 mg
  • 25 mg
  • 5 mg

96-Well PCR Tube Racks, Red

R541-R 1 UNIT
EUR 53.05

100-Well Microtube Racks, Square, Red

RH504-R 1 UNIT
EUR 54.18

Anti-CD63 R-PE antibody

STJ16100872 100 tests
EUR 615

Mouse Monoclonal Anti-Human IgG1 (Fc-region)-PE (phycoerythrin) conjugate

10121-PE 0.5 ml
EUR 408

Mouse Monoclonal Anti-Human IgG2 (Fc-region)-PE (phycoerythrin) conjugate

10122-PE 0.5 ml
EUR 408

Mouse Monoclonal Anti-Human IgG3 (Hinge-region)-PE (phycoerythrin) conjugate

10123-PE 0.5 ml
EUR 408

Mouse Monoclonal Anti-Human IgG4 (Fc-region)-PE (phycoerythrin) conjugate

10124-PE 0.5 ml
EUR 408

Enhanced Green Fluorescent Proteins (EGFP) protein for ELISA or Standards

EGFP16-R 10 ug
EUR 250

A-K-R-R-R-L-S-S-L-R-A

5-00521 4 x 5mg Ask for price

2(R),5(R)-Bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

TBZ0092 unit Ask for price

Hamster Mono Anti-Mouse CD120b (TNF-R, p75), PE (Clone TR75-54.7) (hamster IgG)

MCD120b-PE 100 tests
EUR 408

0.6ML MICROTUBES. RED

MCT-060-R 1000/pk
EUR 183
Description: Micro Tubes; Micro Tubes Push Cap- Axygen

1.7ML MICROTUBES. RED

MCT-175-R 500/pk
EUR 116
Description: Micro Tubes; Micro Tubes Push Cap- Axygen

A-K-R-R-R-L-S-S-L-R-A Peptide

20-abx266604
  • EUR 398.00
  • EUR 244.00
  • EUR 314.00
  • 10 mg
  • 2 mg
  • 5 mg

4-Ways Microtube and Centrifuge Tubes Racks, Red

R023-R 1 UNIT
EUR 53.48

R-Cadherin (R-cadherin) Antibody

abx237200-100ug 100 ug
EUR 481

Recombinant (E. coli) Yellow Fluorescent Proteins (YFP) protein for ELISA or Standards (>98%)

YFP15-R 25 ug
EUR 250

Goat anti Human IgA (R-PE)

43R-1662 100 ug
EUR 194
Description: Goat anti Human IgA antibody conjugated to R-Phycoerythrin

R synuclein protein

30R-3036 200 ug
EUR 354
Description: Purified recombinant R synuclein protein

Streptavidin-Phycoerythrin (PE) conjugate

20369 0.5 ml
EUR 263

R-phycoerythrin goat anti-mouse IgG(H+L), 0.5 mg/mL

9-20352
  • EUR 312.00
  • EUR 149.00
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

R-phycoerythrin goat anti-rabbit IgG(H+L), 0.5 mg/mL

9-20353
  • EUR 312.00
  • EUR 149.00
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

r IGF1R

LVP933 1x107 IFU/ml x 200ul
EUR 451
Description: Pre-made over-expression lentivirus for expressing Rat target: IGF1R ( insulin-like growth factor 1 receptor), [alternative names: IGF-1 receptor; IGFIRC; Igfr1; JTK13]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_052807.2. It also contains a RFP-Blasticidin dual selection marker.

(R)-Sulforaphane

HY-13755A 5mg
EUR 243

(R)-Elagolix

HY-14789 100mg
EUR 946

(R)-Filanesib

HY-15187A 100mg
EUR 1910

(R)-(-)-Gossypol

HY-15464 50mg
EUR 601

(R)-(-)-Rolipram

HY-16900A 50mg
EUR 497

(R)-Baclofen

HY-17354 10mM/1mL
EUR 126

(R)-Oxiracetam

HY-17554 10mM/1mL
EUR 277

IQ-R

HY-18675 50mg
EUR 2116

THZ1-R

HY-19988 1mg
EUR 257

(R)-(-)-Ibuprofen

HY-78131B 10mM/1mL
EUR 186

(R)-Ofloxacin

HY-B0330D 5mg
EUR 911

(R)-Ketorolac

HY-B0580B 10mM/1mL
EUR 176

(R)-(-)-Phenylephrine

HY-B0769 200mg
EUR 119

R-1479

HY-10444 5mg
EUR 533

(R)-FT671

HY-107985A 5mg
EUR 2920

(R)-Equol

HY-108414 10mM/1mL
EUR 141

R-7050

HY-110203 50mg
EUR 521

(R)-(+)-Citronellal

HY-111664 100mg
EUR 119

(R)-BAY1238097

HY-112316A 50mg
EUR 1485

R-10015

HY-120097 10mM/1mL
EUR 492

R-268712

HY-12953 10mg
EUR 340

(R)-Lansoprazole

HY-13662B 500mg
EUR 245

R 80123

HY-100615A 1mg
EUR 173

(R)-Serine

HY-100808 1g
EUR 119

(R)-Simurosertib

HY-100888A 10mg
EUR 418

R-IMPP

HY-101354 10mM/1mL
EUR 148

(R)-Trolox

HY-101445A 10mM/1mL
EUR 138

(R)-Zanubrutinib

HY-101474B 1mg
EUR 268

(R)-Nedisertib

HY-101570A 10mM/1mL
EUR 366

(R)-(+)-Atenolol

HY-B2111 10mM/1mL
EUR 218

(R)-Bicalutamide

E1KS2241 10mg
EUR 325

(R)-Semivioxanthin

GA0013-1MG 1 mg
EUR 298

(R)-Semivioxanthin

GA0013-500UG 500 ug
EUR 206

Opticlear R

NAT1466 EACH
EUR 117

Opticlear R

NAT1468 EACH
EUR 365

(R)-(+)-Pulegone

GL0622-5G 5 g
EUR 90

(R)-Semixanthomegnin

GL1233-1MG 1 mg
EUR 298

(R)-Semixanthomegnin

GL1233-500UG 500 ug
EUR 206

(R)-CR8

GL2908-10MG 10 mg
EUR 321

(R)-CR8

GL2908-1MG 1 mg
EUR 120

(R)-CR8

GL2908-5MG 5 mg
EUR 218

(R)-(-)-Carvone

GL3381-5G 5 g
EUR 44

(R)-Bicalutamide

BC1004-050 50mg
EUR 192

(R)-Bicalutamide

BC1004-100 100mg
EUR 246

(R)-Bicalutamide

BC1004-250 250mg
EUR 394

Granuliberin R

5-01251 4 x 5mg Ask for price

Ranatensin R

5-01868 4 x 1mg Ask for price

R-(+)-Lansoprazole

20-abx186556
  • EUR 551.00
  • EUR 759.00
  • EUR 1205.00
  • 1 g
  • 2 g
  • 5 g

R(-)-Gossypol

20-abx076641
  • EUR 356.00
  • EUR 926.00
  • 10 mg
  • 50 mg

(R)-Methyglycidate

20-abx181457
  • EUR 272.00
  • EUR 1400.00
  • EUR 495.00
  • 1 g
  • 25 g
  • 5 g

(R)-(-)-Epichlorohydrin

abx182749-25g 25 g
EUR 203

(R)-Lisofylline

C4158-1 1 mg
EUR 129
Description: Lisofylline (LSF) is a potent anti-inflammatory agent. LSF is a chiral metabolite of pentoxifylline. (R)-LSF is the biologically active isomer of LSF [1].

(R)-Lisofylline

C4158-10 10 mg
EUR 685
Description: Lisofylline (LSF) is a potent anti-inflammatory agent. LSF is a chiral metabolite of pentoxifylline. (R)-LSF is the biologically active isomer of LSF [1].

(R)-Lisofylline

C4158-5 5 mg
EUR 408
Description: Lisofylline (LSF) is a potent anti-inflammatory agent. LSF is a chiral metabolite of pentoxifylline. (R)-LSF is the biologically active isomer of LSF [1].

(R)-CPP

B6236-10 10 mg
EUR 457

(R)-CPP

B6236-5 5 mg
EUR 267

(R)-AMPA

B6237-10 10 mg
EUR 551

(R)-(+)-Blebbistatin

B6877-10 10 mg
EUR 373
Description: (R)-(+)-Blebbistatin is a cell-permeable non-muscle myosin II ATPases inhibitor with an IC50 range of 2 ?M [1,2]. Non-muscle myosin II (NM II), an actin-binding protein, plays a central role in regulation of cell migration, adhesion and differentiation [4].

(R)-(+)-Blebbistatin

B6877-25 25 mg
EUR 757
Description: (R)-(+)-Blebbistatin is a cell-permeable non-muscle myosin II ATPases inhibitor with an IC50 range of 2 ?M [1,2]. Non-muscle myosin II (NM II), an actin-binding protein, plays a central role in regulation of cell migration, adhesion and differentiation [4].

(R)-(+)-Blebbistatin

B6877-5 5 mg
EUR 221
Description: (R)-(+)-Blebbistatin is a cell-permeable non-muscle myosin II ATPases inhibitor with an IC50 range of 2 ?M [1,2]. Non-muscle myosin II (NM II), an actin-binding protein, plays a central role in regulation of cell migration, adhesion and differentiation [4].

(R)-(+)-Atenolol

C3031-10 10 mg
EUR 328
Description: (R)-(+)-Atenolol is the less active enantiomer of the racemic ?1-adrenergic receptor antagonist, (R, S)-atenolol [1]. Atenolol is a selective ?1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases.

(R)-(+)-Atenolol

C3031-25 25 mg
EUR 659
Description: (R)-(+)-Atenolol is the less active enantiomer of the racemic ?1-adrenergic receptor antagonist, (R, S)-atenolol [1]. Atenolol is a selective ?1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases.

(R)-(+)-Atenolol

C3031-5 5 mg
EUR 206
Description: (R)-(+)-Atenolol is the less active enantiomer of the racemic ?1-adrenergic receptor antagonist, (R, S)-atenolol [1]. Atenolol is a selective ?1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases.

R-7050

C3129-10 10 mg
EUR 224
Description: EC50: 0.631 ?M by TNF-? by ICAM-1 ELISA assayR-7050 is a TNF-? receptor signaling antagonist.TNF-? induces biological activity throgh stimulation of the tumor necrosis factor receptor.

R-7050

C3129-25 25 mg
EUR 398
Description: EC50: 0.631 ?M by TNF-? by ICAM-1 ELISA assayR-7050 is a TNF-? receptor signaling antagonist.TNF-? induces biological activity throgh stimulation of the tumor necrosis factor receptor.

R-7050

C3129-5 5 mg
EUR 154
Description: EC50: 0.631 ?M by TNF-? by ICAM-1 ELISA assayR-7050 is a TNF-? receptor signaling antagonist.TNF-? induces biological activity throgh stimulation of the tumor necrosis factor receptor.

Conantokin-R

B5381-.5 500 ug
EUR 528

R 892

B5395-1 1 mg
EUR 399

R 715

B5420-1 1 mg
EUR 405

(R)-(+)-Tolterodine

B1033-10 10 mg
EUR 283
Description: Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

(R)-(+)-Tolterodine

B1033-100 100 mg
EUR 1636
Description: Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

(R)-(+)-Tolterodine

B1033-5.1 10 mM (in 1mL DMSO)
EUR 209
Description: Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

(R)-(+)-Tolterodine

B1033-50 50 mg
EUR 985
Description: Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

(R)-(-)-Ibuprofen

B1043-100 100 mg
EUR 656
Description: (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.

(R)-(-)-Ibuprofen

B1043-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.

(R)-baclofen

B1531-10 10 mg
EUR 110
Description: (R)-Baclofen is a selective GABAB receptor agonist. GABAB receptors are metabotropic receptors which produce slow inhibitory signals.

(R)-baclofen

B1531-50 50 mg
EUR 261
Description: (R)-Baclofen is a selective GABAB receptor agonist. GABAB receptors are metabotropic receptors which produce slow inhibitory signals.

(R)-(+)-Corypalmine

N2463-20 20 mg
EUR 444
Description: Extracted from ??????;Store the product in sealed, cool and dry condition

Granuliberin-R

H-6800.0001 1.0mg
EUR 126
Description: Sum Formula: C69H103N19O14; CAS# [64704-41-2] net

Granuliberin-R

H-6800.0005 5.0mg
EUR 418
Description: Sum Formula: C69H103N19O14; CAS# [64704-41-2] net

(R)-Crizotinib

A3020-10 10 mg
EUR 108
Description: Crizotinib is a potent, ATP-competitive, small-molecule and orally available inhibitor of c-Met kinase with a Ki value of 4 nmol/L[1].Crizotinib has shown to inhibit wild-type c-Met phosphorylation with a mean IC50 value of 11 nmol/L in multiple human endothelial and carcinoma cell lines.

(R)-Crizotinib

A3020-100 100 mg
EUR 212
Description: Crizotinib is a potent, ATP-competitive, small-molecule and orally available inhibitor of c-Met kinase with a Ki value of 4 nmol/L[1].Crizotinib has shown to inhibit wild-type c-Met phosphorylation with a mean IC50 value of 11 nmol/L in multiple human endothelial and carcinoma cell lines.

(R)-Crizotinib

A3020-5.1 10 mM (in 1mL DMSO)
EUR 137
Description: Crizotinib is a potent, ATP-competitive, small-molecule and orally available inhibitor of c-Met kinase with a Ki value of 4 nmol/L[1].Crizotinib has shown to inhibit wild-type c-Met phosphorylation with a mean IC50 value of 11 nmol/L in multiple human endothelial and carcinoma cell lines.

(R)-Crizotinib

A3020-50 50 mg
EUR 166
Description: Crizotinib is a potent, ATP-competitive, small-molecule and orally available inhibitor of c-Met kinase with a Ki value of 4 nmol/L[1].Crizotinib has shown to inhibit wild-type c-Met phosphorylation with a mean IC50 value of 11 nmol/L in multiple human endothelial and carcinoma cell lines.

(R)-Crizotinib

A3020-S Evaluation Sample
EUR 81
Description: Crizotinib is a potent, ATP-competitive, small-molecule and orally available inhibitor of c-Met kinase with a Ki value of 4 nmol/L[1].Crizotinib has shown to inhibit wild-type c-Met phosphorylation with a mean IC50 value of 11 nmol/L in multiple human endothelial and carcinoma cell lines.

(R)-DPN

B7672-10 10 mg
EUR 486

R-7128

A3747-10 10 mg
EUR 603
Description: R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

R-7128

A3747-5 5 mg
EUR 457
Description: R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

R-7128

A3747-5.1 10 mM (in 1mL DMSO)
EUR 498
Description: R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

R-7128

A3747-50 50 mg
EUR 1495
Description: R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

pExpressNit1-r

PVT17602 2 ug
EUR 258

Angptl4- r

PVT10474 2 ug
EUR 301

pBE2-R

PVT5016 2 ug
EUR 325

(R)-(+)-Etomoxir

B1104-1
EUR 185

Instead of the selection of the characteristics of other properties, we develop a multiparameter method of screening based on four critical parametersscreened simultaneously: fluorescence lifetime, brightness cellular maturation efficiency and photostability.