In this report, we describe the near-infrared fluorescent probes called quinaldine red (QR) is lit β-sheet structure of amyloid fibrils. Photochemical and biophysical properties of QR along with the other canonical probe in the presence of amyloid protein fibrils were investigated using fluorescence spectroscopy, confocal fluorescent microscopy and isothermal titration calorimetry.

Moreover, the binding sites and modes of interaction between QR and insulin fibrils were calculated based on molecular docking. Among these amyloid probe, QR show several advantages including a strong force supramolecular, near-infrared emission, high sensitivity and resistance to bleaching. A linear response of the fluorescence intensity of a sample QR nerve in the presence of sera visualized in the range of 1-30 pM, with a limit of detection (LOD) of 2.31 pM.

Recovery and relative standard deviation (RSD) of the proposed method for the determination of protein fibrils is 90.4% -99.2% and 3.05% -3.47%, respectively. Finally, QR can be fluorescently shine when meeting with aberrant protein aggregates of rat pathogens. We recommend the QR as a new and very good alternative to monitor the transition of the amyloid protein conformation.

A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.
A near-infrared fluorescent probe quinaldine red lights up the β-sheet structure of amyloid proteins in mouse brain.

Dark quantitative determination of pseudo Explains Low Chromophore Population Quantum Yield Red Fluorescent Protein.

The results of four representative fluorescence quantum red fluorescent protein mCherry, mKate2, mRuby2 and recently introduced mScarlet investigated. Durability excited state is measured as a function of the distance to the gold mirror to control the local density of optical states (LDOs). By analyzing the total emission rate as a function of LDOs, we obtain separately the emission level and the level of non-radiation of the sunny countries. Thus we obtain for the first time the results of quantum states of light protein uninterrupted dark, non-emitting state. Bright state quantum yields are much higher than previously reported results of quantum that the average for both bright and dark states.

We determine that mCherry, mKate2 and mRuby2 have a considerable fraction of darker chromophore up to 45%, which explains the low quantum results measured red emitting protein reported in the literature and the difficulty in developing a high quantum results of variants of the protein. To light recently developed mScarlet we find a small dark much smaller than 14%, accompanied by a very high quantum results from sunny countries 81%. The presence of largely dark chromophores have implications for a variety of fluorescent protein applications, ranging from quantitative fluorescence microscopy, FRET studies, to monitor protein expression levels.

We recommend that future optimization of the red fluorescent protein should pay more attention to minimize protein fractions dark. genetically encoded fluorescent protein (FP) are used in cell biology research to study the protein of interest or a signal process using a biosensor. To perform well in certain applications, it requires a lot of properties FP adjusted. It is for this reason that they need to be optimized by using mutagenesis. Process optimization through screening often based on the brightness of the colonies of bacteria, but some parameters ultimately determine the optimal performance of an FP.

R Phycoerythrin antibody

70R-10657 1 mg
EUR 219
Description: Goat polyclonal R Phycoerythrin antibody

R Phycoerythrin antibody

70R-10691 1 mg
EUR 176
Description: Rabbit polyclonal R Phycoerythrin antibody

PE [R-Phycoerythrin] *CAS 11016-17-4*

2556 10 mg
EUR 219

PE [R-Phycoerythrin] *CAS 11016-17-4*

2557 100 mg
EUR 550

PE [R-Phycoerythrin] *CAS 11016-17-4*

2558 1 mg
EUR 115

ReadiUse™ PE [R-Phycoerythrin] *Ammonium Sulfate-Free*

2500 1 mg
EUR 132

ReadiUse™ PE [R-Phycoerythrin] *Ammonium Sulfate-Free*

2501 10 mg
EUR 480

Donkey anti Human IgG (R-Phycoerythrin)

43R-1654 1 ml
EUR 534
Description: Donkey anti Human IgG Secondary Antibody (R-Phycoerythrin)

Rat IgG1-R-PE conjugate (isotype control)

20005-11-PE 25 tests
EUR 202

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20005-12-PE 25 tests
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20005-13-PE 25 tests
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20005-14-PE 50 tests
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20005-21-PE 25 tests
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20007-G1-PE 100 tests
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RFP15-R 25 ug
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9-29044
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Annexin V, R-phycoerythrin conjugate (100 assays)

9-29045
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Hamster IgG-R-PE conjugate, isotype control (Syrian)

20003-1-PE 50 tests
EUR 225

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20009-Fc-PE 100 tests
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20011-FAB2-PE 50 tests
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Safe-Red™

G108-R 1.0 ml
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1P-722-C025 0.025 mg
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Anti-R-RAS2 PE

1P-722-C100 0.1 mg
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80 WELL RED MICROTUBE RACK FOR 1.5/2.0ML MICROTUBES

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R-S-R

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(R,R)-Dipamp

20-abx181460
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(R,R)-THC

B6909-10 10 mg
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(R,R)-Hymeglusin

B1244-1000
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(R,R)-Hymeglusin

B1244-500
EUR 294

Rabbit IgG F(ab')2-R-PE conjugate, isotype control

20009-FAb2-PE 100 tests
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Rat Monoclonal Anti-Mouse CD120a (TNF-R, p55), PE (Clone HM104) (rat IgG2a)

MCD120A-PE 100 tests
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0.65ml Tube, Red, 1000/Bag

BT613-R 1PK, 1000UNIT
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Floating Microtube Racks Octagon, Red

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10121-PE 0.5 ml
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Mouse Monoclonal Anti-Human IgG2 (Fc-region)-PE (phycoerythrin) conjugate

10122-PE 0.5 ml
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10123-PE 0.5 ml
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Mouse Monoclonal Anti-Human IgG4 (Fc-region)-PE (phycoerythrin) conjugate

10124-PE 0.5 ml
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(R,R)-Secoisolariciresinol diglucoside

HY-N6937 5mg
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(R,R)-Palonosetron Hydrochloride

HY-A0021C 10mg
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R-S-R Peptide

20-abx265906
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Anti-CD63 R-PE antibody

STJ16100872 100 tests
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Green Fluorescent Proteins (GFP) protein for ELISA or Standards

GFP15-R 10 ug
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96-Well PCR Tube Racks, Red

R541-R 1 UNIT
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RH504-R 1 UNIT
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Hamster Mono Anti-Mouse CD120b (TNF-R, p75), PE (Clone TR75-54.7) (hamster IgG)

MCD120b-PE 100 tests
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A-K-R-R-R-L-S-S-L-R-A

5-00521 4 x 5mg Ask for price

2(R),5(R)-Bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

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EGFP16-R 10 ug
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A-K-R-R-R-L-S-S-L-R-A Peptide

20-abx266604
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0.6ML MICROTUBES. RED

MCT-060-R 1000/pk
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MCT-175-R 500/pk
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Description: Micro Tubes; Micro Tubes Push Cap- Axygen

R-Cadherin (R-cadherin) Antibody

abx237200-100ug 100 ug
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4-Ways Microtube and Centrifuge Tubes Racks, Red

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43R-1662 100 ug
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Description: Goat anti Human IgA antibody conjugated to R-Phycoerythrin

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YFP15-R 25 ug
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R synuclein protein

30R-3036 200 ug
EUR 354
Description: Purified recombinant R synuclein protein

R-phycoerythrin goat anti-mouse IgG(H+L), 0.5 mg/mL

9-20352
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R-phycoerythrin goat anti-rabbit IgG(H+L), 0.5 mg/mL

9-20353
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Streptavidin-Phycoerythrin (PE) conjugate

20369 0.5 ml
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r IGF1R

LVP933 1x107 IFU/ml x 200ul
EUR 451
Description: Pre-made over-expression lentivirus for expressing Rat target: IGF1R ( insulin-like growth factor 1 receptor), [alternative names: IGF-1 receptor; IGFIRC; Igfr1; JTK13]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_052807.2. It also contains a RFP-Blasticidin dual selection marker.

R 80123

HY-100615A 1mg
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(R)-Serine

HY-100808 1g
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(R)-Simurosertib

HY-100888A 10mg
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R-IMPP

HY-101354 10mM/1mL
EUR 148

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HY-101445A 10mM/1mL
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HY-101474B 1mg
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HY-101570A 10mM/1mL
EUR 366

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HY-10444 5mg
EUR 533

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HY-107985A 5mg
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HY-108414 10mM/1mL
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R-7050

HY-110203 50mg
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(R)-(+)-Citronellal

HY-111664 100mg
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(R)-BAY1238097

HY-112316A 50mg
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R-10015

HY-120097 10mM/1mL
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R-268712

HY-12953 10mg
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HY-13662B 500mg
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HY-13755A 5mg
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HY-14789 100mg
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HY-15187A 100mg
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HY-15464 50mg
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HY-16900A 50mg
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(R)-Baclofen

HY-17354 10mM/1mL
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(R)-Oxiracetam

HY-17554 10mM/1mL
EUR 277

IQ-R

HY-18675 50mg
EUR 2116

THZ1-R

HY-19988 1mg
EUR 257

(R)-(-)-Ibuprofen

HY-78131B 10mM/1mL
EUR 186

(R)-Ofloxacin

HY-B0330D 5mg
EUR 911

(R)-Ketorolac

HY-B0580B 10mM/1mL
EUR 176

(R)-(-)-Phenylephrine

HY-B0769 200mg
EUR 119

(R)-(+)-Atenolol

HY-B2111 10mM/1mL
EUR 218

(R)-Bicalutamide

E1KS2241 10mg
EUR 325

R(-)-Gossypol

20-abx076641
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Ranatensin R

5-01868 4 x 1mg Ask for price

Granuliberin R

5-01251 4 x 5mg Ask for price

(R)-Methyglycidate

20-abx181457
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  • EUR 1400.00
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Instead of the selection of the characteristics of other properties, we develop a multiparameter method of screening based on four critical parametersscreened simultaneously: fluorescence lifetime, brightness cellular maturation efficiency and photostability.